The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease
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چکیده
منابع مشابه
The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease
OBJECTIVE Activation of membrane receptor guanylate cyclase-C (GC-C) is implicated in gastrointestinal fluid and electrolyte balance, preservation of intestinal barrier integrity, anti-trophic effects and inhibition of pain sensation. To evaluate GC-C signaling, we examined the regulation of GC-C (GUCY2C/Gucy2c) and its endogenous ligands guanylin (GN/GUCA2A/Guca2a) and uroguanylin (UGN/GUCA2B/...
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Background: Guanylate cyclase-C (GC-C) signaling pathway via guanylin (Gn) and uroguanylin (Ugn) activation regulates intestinal fluid and electrolyte homeostasis. It is down-regulated in the patients of inflammatory bowel diseases (IBD). However, studies on the role of GC-C signaling in murine models of colitis are controversial. Here, we investigated the effect of GC-C on intestinal inflammat...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Gastroenterology
سال: 2015
ISSN: 0036-5521,1502-7708
DOI: 10.3109/00365521.2015.1038849